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Polyglutamine Solution-State Structural Propensity Is Repeat-Length-Dependent

Expanded polyglutamine (polyQ) tracts in protein, which are known to induce their aggregation, are associated with numerous neurodegenerative diseases. Longer polyQ tracts correlate with faster protein aggregation kinetics and a decreased age of onset for polyQ disease symptoms. Here, we use UV reso...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Jakubek, Ryan S., Workman, Riley J., White, Stephen E., Asher, Sanford A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011583/
https://ncbi.nlm.nih.gov/pubmed/31008597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.9b01433
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