Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA

Aminoglycosides are potent, broad spectrum, ribosome-targeting antibacterials whose clinical efficacy is seriously threatened by multiple resistance mechanisms. Here, we report the structural basis for 30S recognition by the novel plasmid-mediated aminoglycoside-resistance rRNA methyltransferase A (...

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Autores principales: Dunkle, Jack A., Vinal, Kellie, Desai, Pooja M., Zelinskaya, Natalia, Savic, Miloje, West, Dayne M., Conn, Graeme L., Dunham, Christine M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035980/
https://ncbi.nlm.nih.gov/pubmed/24717845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402789111
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