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Tau mutants bind tubulin heterodimers with enhanced affinity
Tau is a microtubule binding protein that forms pathological aggregates in the brain in Alzheimer’s disease and other tauopathies. Disease etiology is thought to arise from loss of native interactions between tau and microtubules, as well as from gain of toxicity tied to tau aggregation, although ne...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4035965/ https://ncbi.nlm.nih.gov/pubmed/24733915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315983111 |
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