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A functional role for intrinsic disorder in the tau-tubulin complex

Tau is an intrinsically disordered protein with an important role in maintaining the dynamic instability of neuronal microtubules. Despite intensive study, a detailed understanding of the functional mechanism of tau is lacking. Here, we address this deficiency by using intramolecular single-molecule...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Melo, Ana M., Coraor, Juliana, Alpha-Cobb, Garrett, Elbaum-Garfinkle, Shana, Nath, Abhinav, Rhoades, Elizabeth
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167143/
https://ncbi.nlm.nih.gov/pubmed/27911791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610137113
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