Ca(2+)-Activated K(+) Channel–3.1 Blocker TRAM-34 Attenuates Airway Remodeling and Eosinophilia in a Murine Asthma Model

Key features of asthma include bronchial hyperresponsiveness (BHR), eosinophilic airway inflammation, and bronchial remodeling, characterized by subepithelial collagen deposition, airway fibrosis, and increased bronchial smooth muscle (BSM) mass. The calcium-activated K(+) channel K(Ca)3.1 is expres...

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Main Authors: Girodet, Pierre-Olivier, Ozier, Annaig, Carvalho, Gabrielle, Ilina, Olga, Ousova, Olga, Gadeau, Alain-Pierre, Begueret, Hugues, Wulff, Heike, Marthan, Roger, Bradding, Peter, Berger, Patrick
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2013
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035224/
https://ncbi.nlm.nih.gov/pubmed/23204391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0103OC
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