The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke

Microglia and brain infiltrating macrophages significantly contribute to the secondary inflammatory damage in the wake of ischemic stroke. Here, we investigated whether inhibition of KCa3.1 (IKCa1/KCNN4), a calcium-activated K(+) channel that is involved in microglia and macrophage activation and ex...

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Hlavní autoři: Chen, Yi-Je, Raman, Girija, Bodendiek, Silke, O'Donnell, Martha E, Wulff, Heike
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323185/
https://ncbi.nlm.nih.gov/pubmed/21750563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.101
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