Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs

BACKGROUND AND PURPOSE: In rodents, the endothelial KCa channels, KCa3.1 and KCa2.3, have been shown to play a crucial role in initiating endothelium-derived hyperpolarizing factor (EDHF) vasodilator responses. However, it is not known to what extent these channels are involved in blood pressure reg...

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Detalhes bibliográficos
Main Authors: Damkjaer, Mads, Nielsen, Gorm, Bodendiek, Silke, Staehr, Mette, Gramsbergen, Jan-Bert, de Wit, Cor, Jensen, Boye L, Simonsen, Ulf, Bie, Peter, Wulff, Heike, Köhler, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252979/
https://ncbi.nlm.nih.gov/pubmed/21699504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01546.x
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