Ca(2+)-Activated K(+) Channel–3.1 Blocker TRAM-34 Attenuates Airway Remodeling and Eosinophilia in a Murine Asthma Model

Key features of asthma include bronchial hyperresponsiveness (BHR), eosinophilic airway inflammation, and bronchial remodeling, characterized by subepithelial collagen deposition, airway fibrosis, and increased bronchial smooth muscle (BSM) mass. The calcium-activated K(+) channel K(Ca)3.1 is expres...

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Detalhes bibliográficos
Main Authors: Girodet, Pierre-Olivier, Ozier, Annaig, Carvalho, Gabrielle, Ilina, Olga, Ousova, Olga, Gadeau, Alain-Pierre, Begueret, Hugues, Wulff, Heike, Marthan, Roger, Bradding, Peter, Berger, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035224/
https://ncbi.nlm.nih.gov/pubmed/23204391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0103OC
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