ALDH+ tumor‐initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ‐secretase inhibitor and irinotecan in colorectal cancer

The Notch signaling pathway has been shown to be upregulated in colorectal cancer (CRC) and important for the self‐renewal of cancer stem cells. In this study, we evaluated the efficacy of PF‐03084014, a γ‐secretase inhibitor, in combination with irinotecan to identify the effects of treatment on tu...

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Autori principali: Arcaroli, John J., Powell, Rebecca W., Varella-Garcia, Marileila, McManus, Martine, Tan, Aik Choon, Quackenbush, Kevin S., Pitts, Todd M., Gao, Dexiang, Spreafico, Anna, Dasari, Arvind, Touban, Basel M., Messersmith, Wells A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2012
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033713/
https://ncbi.nlm.nih.gov/pubmed/22521243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2012.03.004
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