Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity

[Image: see text] Emerging clinical and preclinical evidence suggests that a compound displaying high affinity for μ, κ, and δ opioid (MOP, KOP, and DOP) receptors and antagonist activity at each, coupled with moderate affinity and efficacy at nociceptin opioid peptide (NOP) receptors will have util...

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Hauptverfasser: Kumar, Vinod, Ridzwan, Irna E., Grivas, Konstantinos, Lewis, John W., Clark, Mary J., Meurice, Claire, Jimenez-Gomez, Corina, Pogozheva, Irina, Mosberg, Henry, Traynor, John R., Husbands, Stephen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033651/
https://ncbi.nlm.nih.gov/pubmed/24761755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401964y
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