Modulation of Opioid Receptor Ligand Affinity and Efficacy Using Active and Inactive State Receptor Models

Mu opioid receptor (MOR) agonists are widely used for the treatment of pain; however chronic use results in the development of tolerance and dependence. It has been demonstrated that co-administration of a MOR agonist with a delta opioid receptor (DOR) antagonist maintains the analgesia associated w...

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Hlavní autoři: Anand, Jessica P., Purington, Lauren C., Pogozheva, Irina D., Traynor, John R., Mosberg, Henry I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465523/
https://ncbi.nlm.nih.gov/pubmed/22882801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12014
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