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Placement of Hydroxy Moiety on Pendant of Peptidomimetic Scaffold Modulates Mu and Kappa Opioid Receptor Efficacy

[Image: see text] In an effort to expand the structure–activity relationship (SAR) studies of a series of mixed-efficacy opioid ligands, peptidomimetics that incorporate methoxy and hydroxy groups around a benzyl or 2-methylindanyl pendant on a tetrahydroquinoline (THQ) core of the peptidomimetics w...

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書誌詳細
出版年:ACS Chem Neurosci
主要な著者: Harland, Aubrie A., Pogozheva, Irina D., Griggs, Nicholas W., Trask, Tyler J., Traynor, John R., Mosberg, Henry I.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2017
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691919/
https://ncbi.nlm.nih.gov/pubmed/28796483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00284
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