Novel Dimethyltyrosine-Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show In Vitro Kappa and Mu Opioid Receptor Agonism

The dimethyltyrosine-tetrahydroisoquinoline (Dmt-Tiq) scaffold was originally developed in the production of selective delta opioid receptor (DOR) antagonists. Installation of a 7-benzyl pendant on the tetrahydroisoquinoline core of this classic opioid scaffold introduced kappa opioid receptor (KOR)...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Montgomery, Deanna, Anand, Jessica P., Griggs, Nicholas W., Fernandez, Thomas J., Hartman, Joshua G., Sánchez-Santiago, Ashley A., Pogozheva, Irina D., Traynor, John R., Mosberg, Henry I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726392/
https://ncbi.nlm.nih.gov/pubmed/31199621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.9b00250
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