RECQL5 Controls Transcript Elongation and Suppresses Genome Instability Associated with Transcription Stress

RECQL5 is the sole member of the RECQ family of helicases associated with RNA polymerase II (RNAPII). We now show that RECQL5 is a general elongation factor that is important for preserving genome stability during transcription. Depletion or overexpression of RECQL5 results in corresponding shifts i...

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Hauptverfasser: Saponaro, Marco, Kantidakis, Theodoros, Mitter, Richard, Kelly, Gavin P., Heron, Mark, Williams, Hannah, Söding, Johannes, Stewart, Aengus, Svejstrup, Jesper Q.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032574/
https://ncbi.nlm.nih.gov/pubmed/24836610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.048
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