Mutation of cancer driver MLL2 results in transcription stress and genome instability

Genome instability is a recurring feature of tumorigenesis. Mutation in MLL2, encoding a histone methyltransferase, is a driver in numerous different cancer types, but the mechanism is unclear. Here, we present evidence that MLL2 mutation results in genome instability. Mouse cells in which MLL2 gene...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Kantidakis, Theodoros, Saponaro, Marco, Mitter, Richard, Horswell, Stuart, Kranz, Andrea, Boeing, Stefan, Aygün, Ozan, Kelly, Gavin P., Matthews, Nik, Stewart, Aengus, Stewart, A. Francis, Svejstrup, Jesper Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762426/
https://ncbi.nlm.nih.gov/pubmed/26883360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.275453.115
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