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Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2
We elucidate the molecular mechanisms of two distinct activation strategies (autophosphorylation and TPX2-mediated activation) in human Aurora A kinase. Classic allosteric activation is in play where either activation loop phosphorylation or TPX2 binding to a conserved hydrophobic groove shifts the...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4032492/ https://ncbi.nlm.nih.gov/pubmed/24867643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02667 |
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