Llwytho...
USP15 stabilizes MDM2 to mediate cancer cell survival and inhibit antitumor T cell responses
Deubiquitinases (DUBs) represent a new class of drug targets, although the physiological function of only few DUBs has been characterized. Here we identified the DUB USP15 as a crucial negative regulator of T cell activation. USP15 stabilized an E3 ubiquitin ligase, MDM2, which in turn negatively re...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , , , , , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2014
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4032322/ https://ncbi.nlm.nih.gov/pubmed/24777531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2885 |
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