Lataa...
T cell intrinsic USP15 deficiency promotes excessive IFN-γ production and an immunosuppressive tumor microenvironment in MCA-induced fibrosarcoma
USP15 is a deubiquitinase that negatively regulates activation of naïve CD4(+) T cells and generation of IFN-γ-producing T helper 1 (Th1) cells. USP15 deficiency in mice promotes antitumor T cell responses in a transplantable cancer model; however, it has remained unclear how deregulated T cell acti...
Tallennettuna:
| Julkaisussa: | Cell Rep |
|---|---|
| Päätekijät: | , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2015
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4691552/ https://ncbi.nlm.nih.gov/pubmed/26686633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.046 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|