USP15 stabilizes MDM2 to mediate cancer cell survival and inhibit antitumor T cell responses

Deubiquitinases (DUBs) represent a new class of drug targets, although the physiological function of only few DUBs has been characterized. Here we identified the DUB USP15 as a crucial negative regulator of T cell activation. USP15 stabilized an E3 ubiquitin ligase, MDM2, which in turn negatively re...

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Huvudupphovsmän: Zou, Qiang, Jin, Jin, Hu, Hongbo, Li, Haiyan S., Romano, Simona, Xiao, Yichuan, Nakaya, Mako, Zhou, Xiaofei, Cheng, Xuhong, Yang, Peirong, Lozano, Guillermina, Zhu, Chengming, Watowich, Stephanie S., Ullrich, Stephen E, Sun, Shao-Cong
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032322/
https://ncbi.nlm.nih.gov/pubmed/24777531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2885
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