Glycoengineering of Interferon-β 1a Improves Its Biophysical and Pharmacokinetic Properties

The purpose of this study was to develop a biobetter version of recombinant human interferon-β 1a (rhIFN-β 1a) to improve its biophysical properties, such as aggregation, production and stability, and pharmacokinetic properties without jeopardizing its activity. To achieve this, we introduced additi...

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Hlavní autoři: Song, Kyoung, Yoon, In-Soo, Kim, Nam Ah, Kim, Dong-Hwan, Lee, Jongmin, Lee, Hee Jung, Lee, Saehyung, Choi, Sunghyun, Choi, Min-Koo, Kim, Ha Hyung, Jeong, Seong Hoon, Son, Woo Sung, Kim, Dae-Duk, Shin, Young Kee
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032242/
https://ncbi.nlm.nih.gov/pubmed/24858932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096967
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