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Glycoengineering of pertuzumab and its impact on the pharmacokinetic/pharmacodynamic properties
Pertuzumab is an antihuman HER2 antibody developed for HER2 positive breast cancer. Glycosylation profiles are always the important issue for antibody based therapy. Previous findings have suggested the impact of glycosylation profiles on the function of antibodies, like pharmacodynamics, antibody-d...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5387714/ https://ncbi.nlm.nih.gov/pubmed/28397880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46347 |
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