A Glycoengineered Interferon-β Mutein (R27T) Generates Prolonged Signaling by an Altered Receptor-Binding Kinetics

The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic properties for the glycoengineered protein and its binding partner interaction is unclear. Type I interferon (IFN) receptors, composed of IFNAR1 and I...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Lee, Saehyung, Son, Woo Sung, Yang, Ho Bin, Rajasekaran, Nirmal, Kim, Sung-Su, Hong, Sungyoul, Choi, Joon-Seok, Choi, Jun Young, Song, Kyoung, Shin, Young Kee
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6353837/
https://ncbi.nlm.nih.gov/pubmed/30733680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01568
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