Lead Optimization Studies of Cinnamic Amide EP2 Antagonists

[Image: see text] Prostanoid receptor EP2 can play a proinflammatory role, exacerbating disease pathology in a variety of central nervous system and peripheral diseases. A highly selective EP2 antagonist could be useful as a drug to mitigate the inflammatory consequences of EP2 activation. We recent...

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Main Authors: Ganesh, Thota, Jiang, Jianxiong, Yang, Myung-Soon, Dingledine, Ray
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032197/
https://ncbi.nlm.nih.gov/pubmed/24773616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5000672
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