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Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation
Epoxy FAs (EpFAs) are important lipid mediators that are mainly metabolized by soluble epoxide hydrolase (sEH). Thus, sEH inhibition is a promising therapeutic target to treat numerous ailments. Several sEH polymorphisms result in amino acid substitutions and alter enzyme activity. K55R and R287Q ar...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4031944/ https://ncbi.nlm.nih.gov/pubmed/24771868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M049718 |
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