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Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation

Epoxy FAs (EpFAs) are important lipid mediators that are mainly metabolized by soluble epoxide hydrolase (sEH). Thus, sEH inhibition is a promising therapeutic target to treat numerous ailments. Several sEH polymorphisms result in amino acid substitutions and alter enzyme activity. K55R and R287Q ar...

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Autors principals: Morisseau, Christophe, Wecksler, Aaron T., Deng, Catherine, Dong, Hua, Yang, Jun, Lee, Kin Sing S., Kodani, Sean D., Hammock, Bruce D.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031944/
https://ncbi.nlm.nih.gov/pubmed/24771868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M049718
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