The Membrane-anchored Serine Protease Prostasin (CAP1/PRSS8) Supports Epidermal Development and Postnatal Homeostasis Independent of Its Enzymatic Activity

The membrane-anchored serine protease prostasin (CAP1/PRSS8) is part of a cell surface proteolytic cascade that is essential for epithelial barrier formation and homeostasis. Here, we report the surprising finding that prostasin executes these functions independent of its own enzymatic activity. Pro...

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Detaylı Bibliyografya
Asıl Yazarlar: Peters, Diane E., Szabo, Roman, Friis, Stine, Shylo, Natalia A., Uzzun Sales, Katiuchia, Holmbeck, Kenn, Bugge, Thomas H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2014
Konular:
Cell Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031529/
https://ncbi.nlm.nih.gov/pubmed/24706745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541318
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