A Matriptase-Prostasin Reciprocal Zymogen Activation Complex with Unique Features: PROSTASIN AS A NON-ENZYMATIC CO-FACTOR FOR MATRIPTASE ACTIVATION

Matriptase and prostasin are part of a cell surface proteolytic pathway critical for epithelial development and homeostasis. Here we have used a reconstituted cell-based system and transgenic mice to investigate the mechanistic interrelationship between the two proteases. We show that matriptase and...

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Detalhes bibliográficos
Main Authors: Friis, Stine, Uzzun Sales, Katiuchia, Godiksen, Sine, Peters, Diane E., Lin, Chen-Yong, Vogel, Lotte K., Bugge, Thomas H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696676/
https://ncbi.nlm.nih.gov/pubmed/23673661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.469932
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