The Membrane-anchored Serine Protease Prostasin (CAP1/PRSS8) Supports Epidermal Development and Postnatal Homeostasis Independent of Its Enzymatic Activity

The membrane-anchored serine protease prostasin (CAP1/PRSS8) is part of a cell surface proteolytic cascade that is essential for epithelial barrier formation and homeostasis. Here, we report the surprising finding that prostasin executes these functions independent of its own enzymatic activity. Pro...

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Bibliografische gegevens
Hoofdauteurs: Peters, Diane E., Szabo, Roman, Friis, Stine, Shylo, Natalia A., Uzzun Sales, Katiuchia, Holmbeck, Kenn, Bugge, Thomas H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2014
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031529/
https://ncbi.nlm.nih.gov/pubmed/24706745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541318
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