The Membrane-anchored Serine Protease Prostasin (CAP1/PRSS8) Supports Epidermal Development and Postnatal Homeostasis Independent of Its Enzymatic Activity

The membrane-anchored serine protease prostasin (CAP1/PRSS8) is part of a cell surface proteolytic cascade that is essential for epithelial barrier formation and homeostasis. Here, we report the surprising finding that prostasin executes these functions independent of its own enzymatic activity. Pro...

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Detalhes bibliográficos
Main Authors: Peters, Diane E., Szabo, Roman, Friis, Stine, Shylo, Natalia A., Uzzun Sales, Katiuchia, Holmbeck, Kenn, Bugge, Thomas H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031529/
https://ncbi.nlm.nih.gov/pubmed/24706745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541318
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