The Membrane-anchored Serine Protease Prostasin (CAP1/PRSS8) Supports Epidermal Development and Postnatal Homeostasis Independent of Its Enzymatic Activity

The membrane-anchored serine protease prostasin (CAP1/PRSS8) is part of a cell surface proteolytic cascade that is essential for epithelial barrier formation and homeostasis. Here, we report the surprising finding that prostasin executes these functions independent of its own enzymatic activity. Pro...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Peters, Diane E., Szabo, Roman, Friis, Stine, Shylo, Natalia A., Uzzun Sales, Katiuchia, Holmbeck, Kenn, Bugge, Thomas H.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2014
Θέματα:
Cell Biology
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031529/
https://ncbi.nlm.nih.gov/pubmed/24706745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541318
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