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Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer
[Image: see text] X-ray structures of several ternary product complexes of the catalytic subunit of cAMP-dependent protein kinase (PKAc) have been determined with no bound metal ions and with Na(+) or K(+) coordinated at two metal-binding sites. The metal-free PKAc and the enzyme with alkali metals...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American
Chemical Society
2014
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4030786/ https://ncbi.nlm.nih.gov/pubmed/24786636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5000965 |
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