Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT

To study the catalytic mechanism of phosphorylation catalyzed by cAMP-dependent protein kinase (PKA) a structure of the enzyme-substrate complex representing the Michaelis complex is of specific interest as it can shed light on the structure of the transition state. However, all previous crystal str...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Gerlits, Oksana, Tian, Jianhui, Das, Amit, Langan, Paul, Heller, William T., Kovalevsky, Andrey
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2015
Onderwerpen:
Enzymology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505467/
https://ncbi.nlm.nih.gov/pubmed/25925954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.643213
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