Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site

Proton transfer is integral to many biochemical processes. However, the direct observation and structural characterization of biological proton transfer has hitherto not been possible. Here, neutron crystallography directly locates two protons before and after a pH-induced two-proton transfer betwee...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Gerlits, Oksana, Wymore, Troy, Das, Amit, Shen, Chen-Hsiang, Parks, Jerry M., Smith, Jeremy C., Weiss, Kevin, Keen, David A., Blakeley, Matthew P., Louis, John M., Langan, Paul, Weber, Irene, Kovalevsky, Andrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944821/
https://ncbi.nlm.nih.gov/pubmed/26958828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201509989
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