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Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons

Protein kinases transmit chemical signals by phosphorylating substrate proteins, thus regulating a multitude of cellular processes. cAMP-dependent protein kinase (PKA), a prototypical enzyme for the whole kinase family, has been the focus of research for several decades, however, the details of the...

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Detalhes bibliográficos
Publicado no:Methods Enzymol
Main Authors: Gerlits, Oksana, Weiss, Kevin L., Blakeley, Matthew P., Veglia, Gianluigi, Taylor, Susan S., Kovalevsky, Andrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494206/
https://ncbi.nlm.nih.gov/pubmed/32093838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2019.12.003
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