Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer

[Image: see text] X-ray structures of several ternary product complexes of the catalytic subunit of cAMP-dependent protein kinase (PKAc) have been determined with no bound metal ions and with Na(+) or K(+) coordinated at two metal-binding sites. The metal-free PKAc and the enzyme with alkali metals...

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Hlavní autoři: Gerlits, Oksana, Das, Amit, Keshwani, Malik M., Taylor, Susan, Waltman, Mary Jo, Langan, Paul, Heller, William T., Kovalevsky, Andrey
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030786/
https://ncbi.nlm.nih.gov/pubmed/24786636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5000965
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