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Novel antisense oligonucleotides containing hydroxamate linkages: targeted iron-triggered chemical nucleases
Antisense oligonucleotides with iron binding hydroxamate linkages are designed to act as sequence-selective cleaving agents of complementary nucleic acids through Fenton chemistry. Oligothymidylate analogs with hydroxamate linkages were efficiently synthesized from coupling of nucleoside intermediat...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4030709/ https://ncbi.nlm.nih.gov/pubmed/19184459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-009-9206-7 |
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