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Overlapping and asymmetric functions of TCR signalling during thymic selection of CD4 and CD8 lineages
T cell receptor (TCR) signaling plays a central role in directing developmental fates of thymocytes. Current models suggest TCR signal duration directs CD4 vs CD8 lineage development. To investigate the role of TCR signaling during positive selection directly, we switched signaling off in a cohort o...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4028205/ https://ncbi.nlm.nih.gov/pubmed/24771853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303085 |
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