Efficient (18)F labeling of cysteine containing peptides and proteins using the tetrazine-trans-cyclooctene ligation

(18)F PET has a number of attributes that make it clinically attractive, including nearly 100% positron efficiency, very high specific radioactivity, and short half-life of ~110 min. However, the short half-life of (18)F and the poor nucleophilicity of fluoride introduce challenges for the incorpora...

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Main Authors: Liu, Shuanglong, Hassink, Matthew, Selvaraj, Ramajeyam, Yap, Li-Peng, Park, Ryan, Wang, Hui, Chen, Xiaoyuan, Fox, Joseph M., Li, Zibo, Conti, Peter S.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027965/
https://ncbi.nlm.nih.gov/pubmed/23415400
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