Improved Metabolic Stability for (18)F PET Probes Rapidly Constructed via Tetrazine trans-Cyclooctene Ligation

The fast kinetics and bioorthogonal nature of the tetrazine trans-cyclooctene (TCO) ligation makes it a unique tool for PET probe construction. In this study, we report the development of an (18)F-labeling system based on a CF(3)-substituted diphenyl-s-tetrazine derivative with the aim of maintainin...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Selvaraj, Ramajeyam, Giglio, Benjamin, Liu, Shuanglong, Wang, Hui, Wang, Mengzhe, Yuan, Hong, Chintala, Srinivasa R., Yap, Li-Peng, Conti, Peter S., Fox, Joseph M., Li, Zibo
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492458/
https://ncbi.nlm.nih.gov/pubmed/25679331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00089
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