Conformationally Strained trans-Cyclooctene (sTCO) Enables the Rapid Construction of (18)F-PET Probes via Tetrazine Ligation

The bioorthogonal reaction between tetrazines and trans-cyclooctenes is a method for the rapid construction of F-18 probes for PET imaging. Described here is a second generation (18)F-labeling system based on a conformationally strained trans-cyclooctene (sTCO)—a dienophile that is approximately 2 o...

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Bibliographische Detailangaben
Veröffentlicht in:Theranostics
Hauptverfasser: Wang, Mengzhe, Svatunek, Dennis, Rohlfing, Katarina, Liu, Yu, Wang, Hui, Giglio, Ben, Yuan, Hong, Wu, Zhanghong, Li, Zibo, Fox, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860896/
https://ncbi.nlm.nih.gov/pubmed/27162558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.14742
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