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Design and Synthesis of Highly Reactive Dienophiles for the Tetrazine-trans-Cyclooctene Ligation

Computation was used to design a trans-cyclooctene derivative that displays enhanced reactivity in the tetrazine-trans-cycloctene ligation. The optimized derivative is a (E)-bicyclo[6.1.0]non-4-ene with a cis-ring fusion, in which the eight-membered ring is forced to adopt a highly strained ‘half-ch...

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Main Authors: Taylor, Michael T., Blackman, Melissa L., Dmitrenko, Olga, Fox, Joseph M.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230318/
https://ncbi.nlm.nih.gov/pubmed/21599005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201844c
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