Genetically Encoded Tetrazine Amino Acid Directs Rapid Site-Specific In Vivo Bioorthogonal Ligation with trans-Cyclooctenes

Bioorthogonal ligation methods with improved reaction rates and less obtrusive components are needed for site-specifically labeling proteins without catalysts. Currently no general method exists for in vivo site-specific labeling of proteins that combines fast reaction rate with stable, nontoxic and...

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Autors principals: Seitchik, Jason L., Peeler, Jennifer C., Taylor, Michael T., Blackman, Melissa L., Rhoads, Timothy W., Cooley, Richard B., Refakis, Christian, Fox, Joseph M., Mehl, Ryan A.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369569/
https://ncbi.nlm.nih.gov/pubmed/22283158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2109745
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