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Tropolones As Lead-Like Natural Products: The Development of Potent and Selective Histone Deacetylase Inhibitors
[Image: see text] Natural products have long been recognized as a rich source of potent therapeutics but further development is often limited by high structural complexity and high molecular weight. In contrast, at the core of the thujaplicins is a lead-like tropolone scaffold characterized by relat...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical Society
2013
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027479/ https://ncbi.nlm.nih.gov/pubmed/24900743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400158k |
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