Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors

[Image: see text] Deregulation of HER family signaling promotes proliferation and tumor cell survival and has been described in many human cancers. Simultaneous, equipotent inhibition of EGFR-, HER2-, and HER3-mediated signaling may be of clinical utility in cancer settings where the selective EGFR...

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Autors principals: Barlaam, Bernard, Anderton, Judith, Ballard, Peter, Bradbury, Robert H., Hennequin, Laurent F. A., Hickinson, D. Mark, Kettle, Jason G., Kirk, George, Klinowska, Teresa, Lambert-van der Brempt, Christine, Trigwell, Cath, Vincent, John, Ogilvie, Donald
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027407/
https://ncbi.nlm.nih.gov/pubmed/24900741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400146c
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