Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signalling network is frequently de-regulated in breast cancer and has been shown to mediate resistance to anti-HER2 agents. Whilst constitutive activation of this pathway is emerging as a marker of sensitivity to vari...

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Bibliographic Details
Published in:Int J Oncol
Main Authors: CRAFTER, CLAIRE, VINCENT, JOHN P., TANG, ERIC, DUDLEY, PHILLIPPA, JAMES, NEIL H., KLINOWSKA, TERESA, DAVIES, BARRY R.
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2015
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501645/
https://ncbi.nlm.nih.gov/pubmed/26095475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2015.3062
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