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A combination of AZD5363 and FH5363 induces lethal autophagy in transformed hepatocytes
Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related death worldwide. High Akt activation and aberrant β-catenin expression contribute to HCC cell proliferation, stem cell generation, and metastasis. Several signaling pathway-specific inhibitors are in clinical trials and disp...
Gespeichert in:
| Veröffentlicht in: | Cell Death Dis |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7367822/ https://ncbi.nlm.nih.gov/pubmed/32681102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02741-1 |
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