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A combination of AZD5363 and FH5363 induces lethal autophagy in transformed hepatocytes

Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related death worldwide. High Akt activation and aberrant β-catenin expression contribute to HCC cell proliferation, stem cell generation, and metastasis. Several signaling pathway-specific inhibitors are in clinical trials and disp...

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Foilsithe in:Cell Death Dis
Main Authors: Patra, Tapas, Meyer, Keith, Ray, Ratna B., Ray, Ranjit
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367822/
https://ncbi.nlm.nih.gov/pubmed/32681102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02741-1
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