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Nexus Between Protein–Ligand Affinity Rank-Ordering, Biophysical Approaches, and Drug Discovery

The confluence of computational and biophysical methods to accurately rank-order the binding affinities of small molecules and determine structures of macromolecular complexes is a potentially transformative advance in the work flow of drug discovery. This viewpoint explores the impact that advanced...

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Bibliografiske detaljer
Hovedforfatter: Spies, M. Ashley
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2013
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027140/
https://ncbi.nlm.nih.gov/pubmed/24900579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4003502
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