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Discovery of High-Affinity Protein Binding Ligands – Backwards

BACKGROUND: There is a pressing need for high-affinity protein binding ligands for all proteins in the human and other proteomes. Numerous groups are working to develop protein binding ligands but most approaches develop ligands using the same strategy in which a large library of structured ligands...

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Autors principals: Diehnelt, Chris W., Shah, Miti, Gupta, Nidhi, Belcher, Paul E., Greving, Matthew P., Stafford, Phillip, Johnston, Stephen Albert
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873402/
https://ncbi.nlm.nih.gov/pubmed/20502719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010728
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