Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics

BACKGROUND: Pregnane X receptor (PXR) agonists inhibit liver fibrosis. However, the rodent PXR activator pregnenolone 16α carbonitrile (PCN) blocks, in vitro, hepatic stellate cell-to-myofibroblast trans-differentiation and proliferation in cells from mice with a disrupted PXR gene, suggesting there...

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Detalhes bibliográficos
Main Authors: Marek, Carylyn J, Wallace, Karen, Durward, Elaine, Koruth, Matthew, Leel, Val, Leiper, Lucy J, Wright, Matthew C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688476/
https://ncbi.nlm.nih.gov/pubmed/19432992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-5926-8-1
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