Thermodynamic Additivity of Sequence Variations: An Algorithm for Creating High Affinity Peptides Without Large Libraries or Structural Information

BACKGROUND: There is a significant need for affinity reagents with high target affinity/specificity that can be developed rapidly and inexpensively. Existing affinity reagent development approaches, including protein mutagenesis, directed evolution, and fragment-based design utilize large libraries...

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Detalhes bibliográficos
Main Authors: Greving, Matthew P., Belcher, Paul E., Diehnelt, Chris W., Gonzalez-Moa, Maria J., Emery, Jack, Fu, Jinglin, Johnston, Stephen Albert, Woodbury, Neal W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978705/
https://ncbi.nlm.nih.gov/pubmed/21085650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015432
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